WebFeb 15, 2002 · Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease Xiaoying Hou, 1 Michal Mrug, 1 Bradley K. Yoder, 2 Elliot J. Lefkowitz, 3 Gabriel Kremmidiotis, 4 Peter D’Eustachio, 5 David R. Beier, 6 and Lisa M. Guay-Woodford 1,7 Published February 15, 2002 - More info View PDF Abstract WebImmunofluorescence analysis localized cystin to a small domain on the apical cell surface. Cystin expression appeared to be enriched in the ciliary axonemes, with minor staining in the basal bodies. Fliegauf et al. (2003) cloned human CYS1, which encodes a deduced 158-amino acid protein. The human and mouse proteins share 57% sequence identity.
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